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1. Full name: Le Minh Tuan
2. Sex: Male
3. Date of birh: 22/11/1964
4. Place of birth: Ha Noi, Viet Nam
5. Admission decision number: 212/SĐH, dated: 12/08/2004, of Hanoi National University
6. Changes in academic process: Extension decision number 1132/SĐH.
7. Official thesis title: Study on complexation of some lanthanide elements with L-isoleucine and bioactivity preliminary tests of some synthesized complexes
8. Major: Inorganic Chemistry
9. Code: 62 44 25 01
10. Supervisors: Prof. Dr. Nguyen Dinh Bang
Prof. Dr. Nguyen Trong Uyen
11. Summary of the new findings of the thesis:The study of this thesis is the first study on complexation of some lanthanide elements with L-isoleucine and bioactivity preliminary tests of some synthesized complexes in Vietnam.
The formation of complexes of 12 lanthanides (La3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+, Ho3+, Er3+, Yb3+ and Lu3+) with L-isoleucine were studied and their first stability constants (lg k1) at 250C (I = 0,1; KNO3) were estimated. In aqueous solution, LnIle2+ species were formed and their stability constants increased in succession from La to Lu.
The twelve complexes of 12 lanthanides (La3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+, Ho3+, Er3+, Yb3+ vµ Lu3+) with L-isoleucine were synthesized in the mixture of water-ethanol (50-50% volume) and determined by composition analysis. These complexes were formulated as H3LnIle3(NO3)3.3H2O.
Coordinationof lanthanides with ligand in synthesized complexes was characterized by using different spectrometries (IR, Raman, 13C-NMR and 1H-NMR). The obtained results showed that:
Synthesized complexes were in chelate form.
Free L-isoleucine exists in the form of zwitter ion. In obtained chelates, L-isoleucine acted as a bidentate ligand bonding the lanthanide ions through the nitrogen atom of amino groups and oxygen atom of carboxyl group.
Stimulation effects of lanthanide isoleucine chelates on Hericium erinaceus mushroom were tested:
The La3+ and total light rare earth elements of Dong Pao (cerium are removed) isoleucine chelates had obvious impact on the growth of Hericium erinaceus mushroom.
Suitable doses of lanthanide isoleucine chelates addition (in the range of 100-200 ppm lanthanide) had effect of stimulating the growth, accelerating growth rate of mycelials, increasing biomass volume, weight of fruitbody. When the contents of lanthanide increased further more, they acted as inhibitors and caused the decrease of growth rate of mushroom. With optimal dose lanthanide isoleucine chelates addition, the increase of cultivation yield was 16-21%.
Demonstrated the good performance of light lanthanide compounds (both chelates and nitrate salts) on growth of Hericium erinaceus mushroom and cultivation yields. But the stimulating effects of lanthanide isoleucine chelates were higher and help to increase mushroom cultivation yields of 5-6% compared to that of respectively nitrate salts
12. Practical applicability:
The lanthanide isoleucine chelates had impact on the growth of Hericium erinaceus mushroom.
13. Futher research directions:
Following researches for establishing detail structure of synthesized complexes
Following trial experiments for considering the application capability of synthesized complexes as stimulator for Hericium erinaceus mushroom.
14. Thesis-related publications:
Le Minh Tuan, Nguyen Trong Uyen, Nguyen Đinh Bang (2007), “Synthesis and study on complexes of some lanthanides to L-isoleucine”, Journal of Chemistry, T45, No.DB, pp.1-5.
Le Minh Tuan, Nguyen Trong Uyen, Nguyen Đinh Bang (2008), “Synthesis and study on the complexes of some light rare earth elements with L-isoleucine”, Journal of Science and Technology, T45, No.5, pp. 87 - 91.
Le Minh Tuan, Nguyen Trong Uyen, Nguyen Đinh Bang (2008), “The study on formation of complexes of some lanthanides with L-isoleucine by pH meter titration method”, Journal of Analytical Sciences, T13, No.2, pp.88-91.
Le Minh Tuan, Nguyen Trong Uyen, Nguyen Đinh Bang (2009), “Vibrational spectra investigations of ytterbium chelate with isoleucine as ligand”, Journal of Chemistry, T47, No.5, pp.652-657.
Le Minh Tuan, Nguyen Thi Chinh, Nguyen Trong Uyen, Nguyen Dinh Bang (2009), “Study on efect of light rare earth-isoleucine chelate on HERICIUM ERINACEUM growth”, Journal of Science and Technology, T47, No.5, pp.27-32.
Le Minh Tuan, Nguyen Trong Uyen, Nguyen Dinh Bang (2010), “Synthesis and coordination characterization study of some heavy lanthanides chelate with isoleucine”,Journal of Nuclear Science & Technoloy, No.2, pp.27-32.
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