Mixed-ligand complexes of technetium(V) or rhenium(V) containing tridentate N-[(dialkylamino)(thiocarbonyl)]benzamidine (H₂L¹) and bidentate N,N-dialkyl-N'-benzoylthiourea (HL²) ligands were formed in high yields when (NBu₄)[MOCl₄] (M = Tc or Re) or [ReOCl₃(PPh₃)₂] was treated with mixtures of the proligands. Other approaches for the synthesis of the products are reactions of [MOCl(L¹)] complexes with HL² or compounds of the composition [ReOCl₂(PPh₃)(L²)] with H ₂L¹. The resulting air-stable [MO(L¹)(L ²)] complexes possess potential for the development of metal-based radiopharmaceuticals. [TcO(L¹)(L²)] complexes are readily reduced by PPh₃ with formation of [Tc(L¹)(L ²)(PPh₃)]. The resulting Tc^III complexes undergo two almost-reversible oxidation steps corresponding to one-electron transfer processes. © 2009 Wiley-VCH Verlag GmbH & Co, KGaA.

Nguyen H.H., Deflon V.M., Abram U.

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