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Polymorphism at the apical membrane antigen 1 gene (AMA1) of the malaria parasite plasmodium falciparum in a Vietnamese population

The patterns of molecular evolution of the most diverse region of the apical membrane antigen 1 (AMA1) gene in Plasmodium falciparum from a Vietnamese subpopulation (Bao Loc) were investigated. Within the Bao Loc population, the sequenced gene region showed relatively high allelic and nucleotide diversity (0.985 and 0.02694, respectively). Further, the level of population recombination was substantial, resulting in a significant decay of linkage disequilibrium along the gene region. The results suggest that AMA1 is a useful genetic marker for studying the relationships between adaptation of parasite populations (to the human host immune system) and malaria epidemiology. © 2009 Springer Science+Business Media, LLC.

 Quang N.D., Hoa P.T.P., Tuan M.S., Viet N.X., Jalloh A., Matsuoka H.
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  Từ khóa : apical membrane antigen 1; article; controlled study; DNA polymorphism; evolutionary adaptation; gene linkage disequilibrium; gene locus; genetic variability; housekeeping gene; human; malaria falciparum; molecular evolution; nonhuman; nucleotide sequence; Plasmodium falciparum; population genetics; Viet Nam; Animals; Antigens, Protozoan; Base Sequence; DNA, Protozoan; Gene Frequency; Genetic Variation; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Malaria, Falciparum; Membrane Proteins; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Sequence Analysis, DNA; Vietnam; Plasmodium falciparum