The chromosome passenger complex (CPC) is composed of five proteins: Aurora B kinase, Borealin, INCENP, Survivin and TD-60. CPC functions as an oligo-enzyme, each member activating the catalytic subunit, Aurora B kinase. CPC controls chromosome congression, bidirectional tension on kinetochores and spindle checkpoint signalling as well as cytokinesis completion. CPC is thus a key regulator during mitosis; CPC proteins are exclusively expressed during mitosis and are up-regulated in many tumours. Their overexpression correlates with the level of genomic instability within tumours. Altogether, this leads to the proposal of passenger proteins as potential targets for cancer therapy. This review describes the chromosomal passenger complex and its involvement in mitosis and the different strategies developed towards its inactivation. © 2008 Bentham Science Publishers Ltd.

Hoang T.M.N., Delacour-Larose M., Molla A.

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Từ khóa : 2 aminothiazole derivative; 2,4 dimethyl 5 (2 oxo 1h indol 3 ylmethylene) 3 pyrrolepropionic acid; aminopyrazole derivative; aurora B kinase; aurora kinase inhibitor; azd 1152; borealin protein; cct 129202; chromosomal passenger protein; chromosome protein; cyclopropanecarboxylic acid [4 [4 (4 methyl 1 piperazinyl) 6 (5 methyl 2h pyrazol 3 ylamino) 2 pyrimidinylthio]phenyl]amide; hesperadin; histone H3; imidazopyridine derivative; inner centromere protein; jnj 7706621; n [4 [6 methoxy 7 (3 morpholinopropoxy) 4 quinazolinylamino]phenyl]benzamide; nuclear protein; pha 680632; pha 739358; protein p53; pyrazoloquinazoline derivative; pyrrolopyrazole derivative; survivin; telophase disc 60 protein; triazolediamine derivative; unclassified drug; carcinogenesis; clinical trial; cytokinesis; down regulation; drug efficacy; drug targeting; endometrium carcinoma; enzyme activation; enzyme activity; enzyme inhibition; enzyme phosphorylation; gene overexpression; genomic instability; human; leukemia; malignant neoplastic disease; melanoma; mitosis; nasopharynx carcinoma; protein expression; protein function; protein localization; review; tumor regression; upregulation