Four new furanoditerpenoids, fibrauretin A (1), fibrauretinoside A (2), epi-fibrauretinoside A (3), and epi-2-palmatoside G (4), and a new ecdysteroid glucoside, fibraurecdyside A (5), together with seven known compounds including two furanoditerpenoids (6 and 7), an ecdysteroid (8), and four quaternary protoberberine alkaloids (9-12) were isolated from the stems of Fibraurea tinctoria. The structures of 1-5 were established on the basis of spectroscopic evidence. Among these compounds, palmatine (9) and jatrorrhizine (10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC₅₀ values of 0.9 and 2.1 μM, respectively. © 2007 American Chemical Society and American Society of Pharmacognosy.

Su C.-R., Ueng Y.-F., Nguyen X.D., Reddy M.V.B., Wu T.-S.

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Từ khóa : columbamine; cytochrome P450 3A4; cytochrome P450 inhibitor; epi 12 palmatoside g; epifibrauretinoside a; fibleucinoside; Fibraurea tinctoria extract; fibraurecdyside a; fibrauretin a; fibrauretinoside a; fibraurinoside; jatrorrhizine; ketoconazole; makisterone a; palmatine; plant extract; stepharanine; unclassified drug; article; controlled study; drug isolation; drug structure; enzyme inhibition; Fibraurea tinctoria; medicinal plant; Menispermaceae; nonhuman; plant stem; Cytochrome P-450 Enzyme System; Diterpenes; Enzyme Inhibitors; Furans; Menispermaceae; Molecular Structure; Plant Stems; Plants, Medicinal; Vietnam; Fibraurea tinctoria