From the aerial parts of Scoparia dulcis L. (Scrophulariaceae) grown in Vietnam, four scopadulane-type diterpenoids (4-7), of which 7 is new and was given the trivial name scopadulcic acid C, together with nine known compounds were isolated. Their structures were elucidated by spectroscopic analyses. The absolute con-figurations of 4-7 were ascertained by applying the modified Mosher's method to iso-dulcinol (6). The isolation of the lignans nirtetralin and niranthin for the first time from S. dulcis is also of chemotaxonomic interest. The cytotoxic activity in KB cells, inhibitory effect on LPS/IFNγ-induced NO production, inhibition of multidrug resistance (MDR), and antibacterial and antifungal activities of the scopadulane-type diterpenoids 4-7 were examined in this study. © 2006 Pharmaceutical Society of Japan.

Phan M.G., Phan T.S., Matsunami K., Otsuka H.

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Từ khóa : diterpenoid; dulcidiol; epi scopadulcic acid; gamma interferon; iso dulcinol; lipopolysaccharide; niranthin; nirtetralin; nitric oxide; plant extract; scopadulcic acid c; Scoparia dulcis extract; unclassified drug; antibacterial activity; antifungal activity; article; cancer cell culture; cell strain KB; chemotaxonomy; cytotoxicity; drug isolation; drug structure; human; medicinal plant; minimum inhibitory concentration; multidrug resistance; nonhuman; Scoparia; spectroscopy; Viet Nam; Anisoles; Antibiotics, Antifungal; Antineoplastic Agents, Phytogenic; Dioxoles; Diterpenes; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Interferon Type II; Lignans; Lipopolysaccharides; Nitric Oxide; Scoparia; Scrophulariaceae; Staphylococcus aureus; Tumor Cells, Cultured; Vietnam