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Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis

Ent-kaurane-type diterpenpoids 1-11, isolated from the dried leaves of the endemic Vietnamese medicinal plant Croton tonkinensis Gagnep. (Euphorbiaceae), were evaluated for inhibitory activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) strains. The most active diterpenoids, 2, 3, and 8, exhibited minimum inhibitory concentrations (MICs) of 32, 500, and 125 μg/ml, respectively, against MRSA strains. © 2005 The Japanese Society of Pharmacognosy and Springer.


 Giang P.M., Son P.T., Matsunami K., Otsuka H.
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  Từ khóa : diterpenoid; ent 11alpha acetoxyhydroxykaur 16 en 18 oic acid; ent 15alpha,18 dihydroxykaur 16 ene; ent 18 acetoxy 11apha hydroxykaur 16 en 15 one; ent 18 acetoxy 14apha hydroxykaur 16 en 15 one; ent 18 acetoxy 7beta hydroxykaur 15 one; ent 18 acetoxy 7beta hydroxykaur 16 en 15 one; ent 18 acetoxy 7beta,14alpha dihydroxykaur 16 en 15 one; ent 1alpha acetoxy 7beta,14alpha dihydroxykaur 16 en 15 one; ent 1alpha,14alpha diacetoxy 7beta hydroxykaur 16 en 15 one; ent 1alpha,7beta diacetoxy 14alpha hydroxykaur 16 en 15 one; ent 7beta acetoxy 11apha hydroxykaur 16 en 15 one; kaurene derivative; penicillin G; streptomycin; tetracycline; unclassified drug; antibacterial activity; article; bacterial strain; controlled study; Croton; Croton tonkinensis; drug activity; drug inhibition; drug isolation; Euphorbia; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; nonhuman; plant leaf; Staphylococcus aureus