Twelve natural bis-spirolabdane-type diterpenoids, including eight new, named leoheteronones A-E (3, 6, 8, 9, 11), 15-epileoheteronones B (7), D (10), and E (12), and four known leopersin B (1), 15-epileopersin B (2), leopersin C (4), and 15-epileopersin C (5), together with hispanone (13) and galeopsin (14) were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus Sw. (Lamiaceae) grown in Vietnam. Their structures were determined by spectroscopic analyses. The current study emphasized the accumulation of C-15 oxygenated bis-spirolabdane-type diterpenoids of both 13R and 13S configurations in L. heterophyllus. © 2005 Pharmaceutical Society of Japan.

Giang P.M., Son P.T., Matsunami K., Otsuka H.

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Từ khóa : 15 epileoheteronone b; 15 epileoheteronone d; 15 epileoheteronone e; 15 epileopersin b; 15 epileopersin c; diterpenoid; galeopsin; hispanone; leoheteronone a; leoheteronone b; leoheteronone c; leoheteronone d; leoheteronone e; Leonurus heterophyllus extract; leopersin b; leopersin c; plant extract; unclassified drug; article; drug accumulation; drug determination; drug isolation; drug structure; infrared spectroscopy; Leonurus; Leonurus heterophyllus; medicinal plant; oxygenation; plant growth; Viet Nam; Chromatography, Thin Layer; Diterpenes; Leonurus; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Fast Atom Bombardment