Five new natural labdane-type diterpenoids (5-9), designated leoheteronins A-E, together with four known diterpenoids (1-4), two phytosterols as a mixture of β-sitosterol and stigmasterol, and the flavone genkwanin (10) were isolated from the aerial parts of Leonurus heterophyllus SW. (Lamiaceae) collected in northern Vietnam. Compound 1 was isolated for the first time from a Leonurus species, and 10 is considered to be a chemotaxonomic marker of the Leonurus genus. Their structures were determined using spectroscopic analyses. © 2005 Pharmaceutical Society of Japan.

Giang P.M., Son P.T., Matsunami K., Otsuka H.

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Từ khóa : diterpene; diterpenoid; flavone; genkwanin; labdane; leoheteronin; Leonurus heterophyllus extract; phytosterol; plant extract; sitosterol; stigmasterol; unclassified drug; angiosperm; article; chemical structure; chemotaxonomy; drug isolation; Leonurus; Leonurus heterophyllus; plant identification; spectroscopy; Viet Nam; Chromatography, High Pressure Liquid; Diterpenes; Leonurus; Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared