An array of conducting polymer coaled microelectrodes was employed as an amperometric detector to analyze a range of proteins. Using conducting polymer coatings with different counterions incorporated, varying selectivity series have been obtained. Protein identification and quantification were performed using chemometric techniques such as principal component analysis (PCA), soft independent modelling of class analogy (SIMCA). ordinary least square (OLS) and partial least square (PLS). Using four different polymers, response patterns were obtained and classification of six proteins was achieved. Individual proteins in a two component mixture were quantitatively analyzed with acceptable accuracy.

Lu W., Nguven T.A., Wallace G.G.

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