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INFORMATION ON DOCTORAL THESIS
1. Full name: Nguyen Thi Thanh Mai
2. Sex: Female
3. Date of birth: 24-08-1972
4. Place of birth: Yen Bai
5. Admission decision number: 1892/SĐH Dated: 31/12/2007
6. Changes in academic process:
7. Official thesis title: Study on synthesis and properties of some glucopyranosyl thioureas containing pyrimidine.
8. Major: Organic chemistry
9. Code: 62 44 27 01
10. Supervisor: Assoc.Prof. Dr. Nguyen Dinh Thanh
11. Summary of the new findings of the thesis:
v 34 α,β-unstaturated ketones with productivity from 62 to 839% were synthesized. Products coloured from light yellow to yellow.
v 36 new 2-amino-4 ,6-diarylpyrimidines were prepared from guanidin hydrochloride and α,β-unsaturated ketones in the presence of NaOH using 5 different methods in high yield. Especially, “one-pot” reaction from 3 components was performed:Using classical heating method, refluxing in microwave oven method, using a little solvent in microwave oven method, executing under solvent-free condition in microwave oven, “One-pot” reaction from 3 constituents. Structure of the each product synthesized by these methods is identical.
v 31 new thioureas were synthesized using the two methods: Heating under refluxing in anhydrous dioxane in 56-77%-yield. Microwave-assisted heating in 67-80%-yield. Structure of the each product synthesized by two methods is identical.
v Hydrolysis of five peracetylated glucosyl thioureas by the reaction of sodium methylat in 62-65%-yield.
v Eight 2-iminothiazolidin-4-on were synthesized from corresponding and ethyl bromoacetate in 54-68%-yield.
v The relationships between d and Hammett’s σ in 1H-NMR, 13C-NMR spectra of the 2-amino-4 ,6-diarylpyrimidines and corresponding thioureas were found.
v Themostof2-amino-4,6-diarylpyrimidinesandthioureashavesignificant biological activities (such as antifungal for Candida abbicans, andbacterial for Enterobacter, Staphilocococus epidermidis). The relationships between structure-activity of some 2-amino-4,6-diarylpyrimidines and thioureas were estimated by QSAR method (such as Free-Wilson’s method and Hansch’s model).
12. Practical applicability, if any:
13. Further research directions, if any:
14. Thesis-related publications:
1. Nguyen Dinh Thanh, Nguyen Thị Thanh Mai, Dang Nhu Tai, Pham Hong Lan contribution to synthesis of some 2-amino-4,6-diarylpirimidin, Tuyển tập các công trình khoa học “Kỷ niệm 50 năm thành lập khoa Hoá học, trường ĐHTH Hà Nội 1956-2006”, Hà Nội 10/2006, tr. 104-108.
2. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, High-resolution mass spectra of some 1-(2’,3’,4’,6’-tetra-O-acetyl-b-D-glucopyranosyl)-3-(4”,6”-diarylpyrimidine-2”-yl)thioureas, Journal of Science and Technology, T. 45, N. 1B, pp. 202-209 (2007).
3. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, 1-(2’,3’,4’,6’-tetra-O-acetyl-b-D-glucopyranosyl)-3-(4”,6”-diarylpyrimidine-2”-yl)thioureas, 11th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-11), 1-30 November 2007 (MDPI), A030.
4. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Biological activities of some 2-amino-4,6-diarylpyrimidin and corresponding thioureas compound, Tuyển tập báo cáo Hội nghị toàn quốc “Khoa học và Công nghệ Hoá Dược”, lần thứ nhất, Hà Nội 12/2008, tr. 160-168.
5. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Syntheis of some derivatives of 1-(2’,3’,4’,6’-tetra-O-acetyl-b-D-glucopyranosyl)-3-(4”,6”-diarylpyrimidine-2”-yl)-thioureas, Journal of Chemistry, T.46, N.1, pp. 102-107 (2008).
6. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, NMR spectra of some N-(tetra-O-acetyl-b-D-glucopyranosyl)-N’-(4’,6’-diarylpyrimidine-2’-yl)thioureas, Journal of Analytical Sciences, T. 14, 165-170(2009).
7. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Tran Thi Ha Thu, Synthesis of some N-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-N’- [4’-(p-bromophenyl)-6’-arylpyrimidine-2’-yl]thioureas, Journal of Chemistry, T.47, N.4A, tr.217-222 (2009).
8.Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Synthesis of N-tetra-O-acetyl-b-D-glucopyranosyl-N’-(4’,6’-diarylpyrimidine-2’-yl)thioureas, Carbohydr. Res., Vol. 344 ,2399-2405 (2009).
9. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Synthesis of some N-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-N’-4’- [(p-methoxyphenyl)-6’-arylpyrimidine-2’-yl]thioureas, Journal of Chemistry, (2009)..
10. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Synthesis of 2-iminothiazolidin-4-ones from N-(per-O-acetyl-β-D-glucopyranosyl)-N’-(4’,6’-diarylpyrimidine-2’-yl)thioureas,VNU Journal of Science and, Natural Sciences and Technology , T. 25, 273-280 (2009).
11. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Synthesis of some 2-amino-4,6-diarylpyrimidine derivatives using microwave-assisted method, Journal of Chemistry (2009).
12. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Bui Thi Thu Trang,Analysis of NMR spectra of N-(per-O-acetyl-b-D-glucopyranosyl)-N’- [4’-(p-methoxyphenyl)-6’-arylpyrimidine-2’-yl]thioureas, Journal of Analytical Sciences (2009).
13. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Analysis of NMR spectra of N-(per-O-acetyl-b-D-glucopyranosyl)-N’- [4’-(p-bromophenyl)-6’-arylpyrimidine-2’-yl]thioureas, Journal of Analytical Sciences (2009).
14. Nguyen Dinh Thanh, Nguyen Thi Thanh Mai, Microwave-Assisted synthesis of N-Tetra-O-Acetyl-β-D-glucopyranosyl)-N’-(4’,6’-diarylpyrimidine-2’-yl)thioureas.13rd international Electronic Conference on Synthetic Organic Chemistry (ECSOC-13), 1-30 November 2009.
Hanoi, 08 April 2010
Candidate
Nguyen Thi Thanh Mai
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