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Official thesis title: Synthesis and properties of some acetamidoaryl-1,3,4-oxadiazol-2-thiol
1. Full name: NGUYEN THI SON
2. Sex: Female
3. Date of birth: 24/4/1979
4. Place of birth: Hanoi
5. Admission decision number: 2259/SĐH, date 7/12/2006 by President of Vietnam National University, Hanoi.
6. Changes in academic process: None
7. Official thesis title: Synthesis and properties of some acetamidoaryl-1,3,4-oxadiazol-2-thiol.
8. Major: Organic Chemistry
9. Code: 62 44 27 01
10. Supervisors: Assoc.Prof.Dr.Sc. Luu Van Boi
11. Summary of the new findings of the thesis
- Have been synthesized 7 acetamidobenzoyl hydrazide derivatives from este of cacboxylic acid by microwave-assisted method. The experimental results showed that the yields were the same while reaction time was 9-10 h shorter compared with the conventional methods;
- Have been succesfully applied the new, effective and more environmentally friendly method - thiocacbamoylation of acetamidobenzoyl hydrazides by tetramethylthiuram disulphide for synthesis of 7 new 5-(acetamidoaryl)-1,3,4-oxadiazole-2-thiols;
- Have been carried out the reaction between obtained 5-(acetamido-aryl)-1,3,4-oxadiazole-2-thiols with α-chloacetanilide. The experimental results showed that in alkaline medium and with temperature of above 600C reaction transformed further to form 5-(acetamidoaryl)-2-arylamino-1,3,4-oxadiazole, exception is for N-α-chloacetanilide containing NO2 group in benzen ring;
- Have been determined the mechanism of transformation of 2-(N-4-R-arylcacboxamidomethylthio)-5-(acetamidoaryl)-1,3,4-oxadiazole; there is internal molecular attack of generated in alkaline medium amide anion on carbon atom C-2 of oxadiazole ring to form 5-(acetamidoaryl)-2-arylamino-1,3,4-oxadiazole and thioglycolic acid;
- Have been optimized the conditions of the reaction between 5-(acetamidoaryl)-1,3,4-oxadiazole-2-thiols with α-chloacetanilides and succesfully synthesized 50 new 2-(N-arylcacboxamidomethylthio)-5-(acetamidoaryl)-1,3,4-oxadiazoles and 18 5-(acetamidoaryl)-2-arylamino-1,3,4-oxadiazoles;
- Have been researched on identification of the obtained products by IR-, MS- and NMR spectroscopy. Results showed that their structure met the earlier predicted;
- Have been tested the biological activities of obtained 2-(N-arylcacboxamidometylthio)-5-(acetamidoaryl)-1,3,4-oxadiazoles. Test results showed that the most of synthesized substances process anti-bacterial and anti-fungal activities.
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