1. Full name: Do Son Hai                                               2. Sex: Male

3. Date of birth: 14 August 1982                                     4. Place of birth: Nam Dinh province

5. Admission decision number: No. 3713/QĐ-ĐHKHTN dated on 09 September 2014

6. Changes in academic process: Non.

7. Official thesis title: Study on synthesis and conversion of some 2-amino-4H-pyran-3-carbonitriles.

8. Major: Organic chemistry                                           9. Code: 62440114

10. Supervisors: Prof. Dr. Nguyen Dinh Thanh

11. Summary of the new findings of the thesis:

- Twelve compounds of substituted propargyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylate have been synthesized using three-component synthetic method; 11 compounds of substituted 2-amino-4-phenyl-7-propargyloxy-4H-chromene-3-carbonitriles have been prepared by the Williamson’s ether reaction from corresponding substituted 2-amino-4-phenyl-7-hydroxy-4H-chromene-3-carbonitriles; and 5 compounds of ethyl 2,7-dimethyl-5-(phenyl)-4-oxo-3-propargyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine-6-carboxylates. All obtained compounds were new.

- Eleven compounds of substituted ethyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylates have been synthesized by the novel methods using ionic liquid as a catalyst in the three-component synthetic method. Five compounds in this series were converted into 8 compounds of 4H-pyrano[2,3-d]pyrimidine type and 4 compounds of substituted tetrahydropyridine type by reaction with to dichloroacetyl chloride, or acetic anhydride. All obtained transformation products were new.

- Especially, the main contributions of thesis were the use of click chemistry in the synthesis of 1H-1,2,3-triazoles containing D-glucose moiety and 4H-pyran ring and similar heterocyclic rings (4H-chromene, 4H-pyrano[2,3-d]pyrimidine), such as 9 compounds of substituted ethyl 1-((2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)methyl-6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylates; 9 compounds of substituted 2-amino-4-phenyl-7-((1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)methoxy)-4H-chromen-3-carbonitriles and 5 compounds of ethyl 3-(1-((2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl))-1H-1,2,3-triazol-4-yl)methyl-2,7-dimethyl-5-(phenyl)-4-oxo-3,5-dihydro-4H-pyrano[2,3-d]pyrimidin-6-carboxylates. All obtained 1H-1,2,3-triazoles were new.

12. Paratical applicability, if any: In progress.

13. Further research directions, if any:

- Study on synthesis of some compounds of 1H-1,2,3-triazoles containing 4H-pyran or 4H-chromene and other monosarcharide or disarcharid moieties (such as d-galactose, d-lactose, d-maltose).

- Study on estimation the another biological activity on some other microorganisms to find the unique biological properties for suitable microorganisms.

14. Thesis-related publications:

[1] Nguyen Dinh Thanh, Do Son Hai, Tran Thi Dung, Nguyen Thi Mai, Le Hai Dang (2016), “Synthesis on the Use of the ionic liquid 1-butyl-3-methylimidazolium hydroxidee in synthesis of substituted 4-phenyl-4H-chromenes”, VNU Journal of Science: Natural Sciences and Technology, 32(3), pp.176-180.

[2] Do Son Hai, Nguyen Dinh Thanh, Cao Thi Le, Vu Thi Tuyet Thuy, Do Tien Tung, Hoang Thi Kim Van, Nguyen Thi Minh Hai (2017), “Synthesis of some substituted propargyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylates”, Viet Nam Journal of Chemistry, 55(5E1,2), pp.468-473.

[3] Do Son Hai, Nguyen Dinh Thanh, Pham Thi Thu Hien, Vu Thi Ng°C Bich, Nguyen Thi Ky Duyen, Nguyen Thi Mai (2017), “Study on synthesis of some propargyl ethers of substituted 2-amino-4-phenyl-7-hydroxy-4H-chromene-3-carbonitriles”, Viet Nam Journal of Chemistry, 55(2e), pp.156-160.

[4] Do Son Hai, Nguyen Dinh Thanh, Cao Thi Le, Vu Thi Tuyet Thuy, Do Tien Tung, Hoang Thi Kim Van (2018), “Analysis of NMR spectra of substituted propargyl 6-ammino-5-cyano-2-methyl-4-R-phenyl-4H-pyran-3-carboxylate”, VietNam Journal of Analytical Sciences, 23, pp.172-177.

[5] Do Son Hai, Nguyen Dinh Thanh, Cao Thi Le, Vu Thi Tuyet Thuy, Do Tien Tung (2017), “Synthesis of 2-amino-4H-pyran-3-carbonitriles: its reaction to chlorocetyl chloride” The 21st International electronic conference on synthetic organic chemistry, Vol.21, 2017, http://sciforum.net/conference/ecsoc-21/paper/ 4770.

[6] Do Son Hai, Nguyen Dinh Thanh, Cao Thi Le, Vu Thi Tuyet Thuy, Do Tien Tung, Hoang Thi Kim Van (2017), “Catalysis investigation of 2-amino-4H-pyran-3-carbonitriles containing propargyl group”, In proceeding of the 21th International Electronic Conference on Synthetic Organic Chemistry, Vol.21, 2017, http://sciforum.net/conference/ecsoc-21/paper/4769.

[7] Nguyen Dinh Thanh, Do Son Hai, Pham Thi Thu Hien, Vu Thi Ngoc Bich, Hoang Thi Kim Van (2018), “Synthesis of some 1H-1,2,3-triazols containing chromene and d-glucose moieties”, Viet Nam Journal of Chemistry (accepted).

[8] Nguyen Dinh Thanh, Nguyen Thi Thu Ha, Do Tien Tung, Cao Thi Le, Tran Thi Thanh Van, Do Son Hai, Hoang Thi Kim Van, Vu Ngoc Toan (2018), “Application of spectral methods for study on conversion of 2-amino-4H-pyran-3-carbonitriles”, VietNam Journal of Analytical Sciences (accepted).