1. Full name: Ta Thu Hang                                              2. Sex: Female

3. Date of birth: 03-11-1975                                            4. Place of birth: Ninh Binh

5. Admission decision number: Number  2048/QĐ-SĐH  dated on 09th July, 2010 by President of Vietnam National University, Hanoi

6. Changes in academic process: No

7. Official thesis title: Study on biological activity of hypoglycemia and cholesterol of some main groups of Nopal (Opuntia sp.) plants imported into Vietnam.

8. Major: Biochemistry                                                   9. Code: 62420116

10. Science Supervisors:          

+ Main supervisor: Assoc. Prof. Le Tat Khuong

+ Additional supervisor: Assoc. Prof. Nguyen Van Mui

11. Summary of the new findings of the thesis

- Identification of one cultivar Nopal cultivated in Vietnam with the best blood glucose lowering effect: Jalpa.

- Determine the nutritive composition, qualitative groups of substances, isolate, determine the structure and name the compounds in the ethylacetate high segment of the plant. Ethylacetate is highly selective for hypoglycaemia, cholesterol and the ability to activate p-AMPK and p-ACC.

- Identify 01 substance is Typhaneosid, characteristic in Jalpa cactus which actives p-AMPK and p-ACC, inhibits FAS (fatty acid synthesis), increases glucose uptake in cells.

12. Paratical applicability, if any:

Make use of the nopal cactus material grown in Ninh Thuan to prevent sand mobility in the dry zone and to use as medicinal herbs material, plant extracts that can be used as a supportive drug for diabetes mellitus. meaningful matters.

The selection of segment with hypoglycemic efficacy superior to that of other Jalpa cactus species will contribute to the identification of active ingredients from this segment. On the other hand, in the industrial production, the selection of high-throughput fractions will have a certain effect on productivity and economic efficiency.

Selection of typhaneosides as the major and specific component of the Jalpa cactus cultivar belonging to the genus Opuntia ficus indica, activating p-AMPK and p-ACC, inhibiting FAS (fatty acid synthesis), increasing glucose uptake in the cell of this compound is intended as a marker active substance for medicinal and pharmaceutical products in the future.

13. Further research directions, if any

+ In-depth study of in-vitro and in-vivo pharmacological mechanisms to evaluate the effects of typhaneosid on obesity, type 2 diabetes

+ Continue research to determine the mechanism of action: such as evaluating the effect of the Nopal trunk on a number of specific targets such as amylase, on PPARγ ...

+ Assessment of safety in experimental animals: subchronic toxic, reproductive and development toxic, mutation toxic, carcinogenesis.

14. Thesis-related publications:

[1] Ta Thu Hang, Le Tat Khuong, Pham Thi My Phuong, Nguyen Van Lam, Nguyen Tien Duy (2012), "Biochemical composition of some Nopal varieties in dryland in Ninh Thuan", Science and technology, 638 (7), p. 93-96.

[2] Ta Thu Hang, Dao Van Minh, Le Tat Khuong, Nguyen Van Mui, Doan Thi Bac (2016), "Study on Morphological and Microscopic Characteristics of Nopal Cactus", Journal of Pharmacy, 487 (11), p. 30-34.

[3] Ta Thu Hang, Dao Van Minh, Le Tat Khuong, Nguyen Van Mui, To Le Hong (2016), "Chemical composition of Ethyl acetate extract from Nopal planted in Ninh Thuan", Journal of medicinal , 21 (6), pp. 372-378.

[4] Ta Thu Hang, Le Tat Khuong, Doan Thi Bac, Dao Van Minh (2017), "Effects of increased glucose uptake and FAS inhibition via p-AMPK activation in Typhaneosid 3T1-L1 cells from plants Cultivated Nopal dragon in Vietnam ", Journal of Medicine, 22 (4), pp. 247-254.

[5] Ta Thu Hang, Le Tat Khuong, Doan Thi Bac (2018), "Effects of hypoglycaemia and lipid peroxidation of cactus Jalpa in type 2 diabetes mellitus, Journal of Pharmacy, 501(1), pp. 12-16.