1. Full name:Tran Hong Tram                                                      2. Sex: Female

3. Date of birth: 03 May 1976                                                     4. Place of birth: Hanoi

5. Admission decision number:  No. 4374/QĐ-KHTN-CTSV, dated on 3rd December 2012, signed by the Rector of VNU University of Science

6. Changes in academic process: Extention according to: Decision No. 741/QĐ-ĐHKHTN date on 31st March 2016 and Decision No. 1034/QĐ-ĐHKHTN date on 25th April 2017,  signed by the Rector of VNU University of Science;

7. Official thesis title: Applying Limiting-Antigen Avidity EIA and False Recent Rate for estimating HIV incidence on some high risk groups in Vietnam.

8. Major: Microbiology                                                               9. Code: 62 42 01 07

10. Supervisors: Assoc.Prof.Dr. Nguyen Anh Tuan & Assoc.Prof.Dr. Nguyen Quang Huy

11. Summary of the new findings of the thesis

The False Recent Rate were confirmed by using BED-CEIA and LAg-Avidity assay: False Recent Rate (FRR) of BED – CEIA is 1,7% (95 CI: (1,2-2,4) and False Recent Rate of LAg-Avidity is 1,2% (95 CI: 0,8-1,9).

Applying False Recent Rate for estimating HIV incidence in some high risk groups in Vietnam:  

12. Paratical applicability, if any: Ministry of Health (MOH) in Vietnam intend to apply LAg-Avidity in HIV Sentinel Surveillance program (including 20 provinces) for finding the “hot sites” that transmit HIV infection; Pre-exposure prophylaxis for partner of HIV infection person giving them a good intervention in high risk groups.. MOH Vietnam also made a plan applying LAg-Avidity in the national strategy for diagnosing HIV infection.

13. Further research directions, if any:

- Collecting data of HIV incidence for creating a new HIV diagnostic strategy that suitable to Vietnam situation (WHO/UNAIDS recommendation).

- Validating HIV incidence quick test assay- Asante Recency (developing from LAg-Avidity) for conducting HIV test easier in fields.

14. Thesis-related publications:

[1] Nguyen Anh Tuan, Hoang Thi Thanh Ha, Nguyen Tran Hien, Tran Hong Tram (2013), “quantify and compare the local misclassification rates using BED and LAg-Avidity assay for estimating HIV-1 incidence in Vietnam”, Journal of Preventive Medicine (889+890), pp. 52-57.

[2] Nguyen Anh Tuan, Tran Hong Tram, Pham Hong Thang, Hoang Thi Thanh Ha, Nguyen Tran Hien (2013), “Estimating False Recent Rate by using LAg-Avidity assay”, Journal of Preventive Medicine (889+890), pp. 46-51.

[3] Neha S. Shah, Yen T. Duong, Linh-Vi Le, Nguyen Anh Tuan, Tran Hong Tram, Andrea A. Kim (2017), “Estimating False-Recent Classification for the Limiting-Antigen Avidity EIA and BED-Capture Enzyme Immunoassay in Vietnam: Implications for HIV-1 Incidence Estimates”, AIDS Research and Human Retroviruses, 33(6), pp. 546-554,

[4] Tran Hong Tram, Nguyen Anh Tuan, Nguyen Quang Huy (2018), “Assays of determining recent HIV and algorithms for estimating HIV incidence rates”, Journal of Preventive Medicine 28 (2), pp. 19 -29