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1. Full name: Truong Thi To Chinh
2. Sex: Female
3. Date of birth: 21/5/1973
4. Place of birth: Hưng Yên
5. Admission decision number 2259/SĐH of December 7, 2006 of Vietnam National University, Hanoi, Viet Nam
6. Changes in academic process: The study was extended for 1 year according to the decision number 2303/QĐ-CTSV of September 11, 2009 of Hanoi University of Science.
7. Official thesis title:
Study on the chemical constituents of some species of the families Betulaceae and Zingiberaceae
8. Major: Organic Chemistry
9. Code: 62 44 27 01
10. Supervisors:
Prof. Dr. Sc. Phan Tong Son
Assoc. Prof. Dr. Phan Minh Giang
11. Summary of the new findings of the thesis:
▪ For the first time the chemical constituents of Alnus nepalensis D. Don (Betulaceae) were studied; twenty one compounds were isolated. The leaves gave eighteen compounds including seven triterpenoids, three flavonoids, and three diarylheptanoids. The twigs gave five compounds of which one compound, betulin, has not been found in the leaves. The stem bark gave five compounds including betulin, taraxerone and -sitosterol.
Compounds which were isolated from the Alnus nepalensis D. Don are taraxeryl acetate, physcion, 1-nonacosanol, heptacosanoic acid, quercetin, -sitosterol-3-O--D-glucopyranoside, quercitrine, taraxerol, 22-hydroxyhopan-3-one, 2-hydroxydiploterol, betulinic acid, mangiferonic acid, 24(E)-3-oxodammaran-20(21)-24(25)-dien-27-oic acid, 1,5-epoxy-1(3ʹ,4ʹ-dihydroxyphenyl-7-(4ʹʹ-hydroxyphenyl)heptane, bis-(4-hydroxyphenyl)heptan-3-ol, hirsutenone, gallic acid, quercetin-3-O--D-galactopyranoside, betulin, taraxerone, and -sitosterol; among them, 1,5-epoxy-1-(3ʹ,4ʹ-dihydroxyphenyl-7-(4ʺ-hydroxyphenyl)heptane is a new substance; 2-hydroxydiploterol was isolated for the first time from the plant, and mangiferonic acid, 24(E)-3-oxodammaran-20(21)-24-dien-27-oic acid and physcion were isolated for the first time from the Betulaceae family.
▪ For the first time Betula alnoides Buch.-Ham. ex D. Don (Betulaceae) was studied in depth on the chemical composition; sixteen compounds and two compound mixtures were isolated. The leaves gave eleven compounds and a mixture of two compounds. The twigs gave three compounds of which lupeol and betulin have not been found in the leaves. In addition, the stem bark gave two chemical markers, taraxeryl acetate and taraxeron, and a mixture of two organic acids.
Compounds isolated from Betula alnoides Buch.-Ham. ex D. Don were hexacosanoic acid, -sitosterol, ovalifoliolide B, chrysoeriol, kaempferol 7-O-methyl ether, 1-O-(24-tetracosanoyl)glycerol, quercetin, betalnoside A, betalnoside B, -sitosterol 3-O--D-glucopyranoside, isoquercitrine, betalnoside C, rutin, lupeol, betulin, taraxeryl acetate, taraxerone, betulinic acid, oleanolic acid, and ursolic acid; among them betalnoside A, betalnoside B, and betalnoside C are new substances, ovalifoliolide B was isolated for the first time from Betulaceae family, taraxeryl acetate, taraxerone, and 1-O-(24-tetracosanoyl)glycerol were isolated for the first time from Betula species.
▪ For the first time Zingiber penisulare I. Theilade was studied on its chemical composition. Nine compounds were isolated from the rhizomes of this plant, eicosanoic acid, 5-hydroxy-3,4ʹ,7-trimethoxyflavone, -sitosterol, 6-hydroxystigmast-4-en-3-one, 4ʹ,5-dihydroxy-7-methoxyflavonol, 4ʹ,5-dihydroxy-3,7-dimethoxyflavon, 1-O-[(26-feruloyloxyhexacosanoyl)]glycerol, 1-O-(28-hydroxy octacosanoyl)glycerol, and vanillic acid; among them 1-O-[(26-feruloyloxyhexacosanoyl)]glycerol and 1-O-(28-hydroxyoctacosanoyl)glycerol were isolated for the first time from the family Zingiberaceae.
▪ The first chemical study on the chemical constituents of Alpinia maclurei Merr. led to the isolation of five compounds from the rhizomes of this plant; -sitosterol, palmitic acid, alpininon, narigenin 5-O-methyl ether, and -sitosterol-3-O--D-glucopyranoside.
▪ The antimicrobial activity of eight triterpenoid and steroid compounds were evaluated in this study; among them taraxerone showed antibacterial activity against Pseudomonas aeruginosa and taraxeryl acetate showed antibacterial and antifungal activities against Pseudomonas aeruginosa and Aspergillus niger.
12. Practical applicability:
- The study provides a collection of natural compounds which can be used for the study to develop antibacterial, antioxidative, and anticancer drugs.
13. Further research direction:
- Isolation of the useful compounds in larger scale.
- Evaluation of the various biological activities of the compounds isolated.
14. Thesis-related publications:
1. Truong Thi To Chinh, Phan Minh Giang, Phan Tong Son (2008), “Chemical constituents of the leaves of Alnus nepalensis D. Don (Betulaceae)”, JournalofChemistry (Viet Nam), Vol. 46 (4), pp. 521-525.
2. Truong Thi To Chinh, Phan Minh Giang, Phan Tong Son (2009), “A fatty acid, flavonoids and steroids from Zingiber penisulare I. Theilade (Zingiberaceae)”, JournalofChemistry (Viet Nam), Vol. 47 (3), pp. 388-392.
3. Minh Giang Phan, Thi To Chinh Truong, Tong Son Phan, Katsuyoshi Matsunami, Hideaki Otsuka (2010), “Mangiferonic acid, 22-hydroxyhopan-3-one, and physcion as specific chemical markers for Alnus nepalensis”, Biochemical Systematics and Ecology, Vol. 38 (5), pp. 1065-1068.
4. Phan Minh Giang, Truong Thi To Chinh, Phan Tong Son, “Structure determination of mangiferonic acid from Alnus nepalensis D. Don (Betulaceae) by NMR spectra”, Abstract Proceedings of Scientific Conference of Hanoi University of Science, Vietnam National University, Hanoi, October 6, 2010, Hanoi, Viet Nam, p. 74.
5. Phan Minh Giang, Truong Thi To Chinh, Phan Tong Son, “Isolation of flavonoid compounds from Betula alnoides Buch. -Ham. (Betulaceae)”, Abstract Proceedings of Scientific Conference of Hanoi University of Science, Vietnam National University, Hanoi, October 6, 2010, Hanoi, Viet Nam, p. 74.
6. Trương Thi To Chinh, Phan Minh Giang, Dao Thi Hang, Phan Tong Son (2010), “Chemical constituents of Zingiber penisulare I. Theilade (Zingiberaceae)”, JournalofChemistry (Viet Nam), Vol. 48 (4B), pp. 512-515.
7. Trương Thi To Chinh, Phan Minh Giang, Nguyen Thi Quyen, Nguyen Thi Thoi, Duong Thi Hai Yen, Phan Tong Son (2010), “Chemical constituents of Alpinia speciesof Viet Nam (Zingiberaceae)” JournalofChemistry (Viet Nam), Vol. 48 (4B), pp. 501-505.
8. Trương Thi To Chinh, Phan Minh Giang, Phan Tong Son, “Glycerol monoesters from Zingiber penisulare”, JournalofChemistry (Viet Nam), Vol. 48 (5B), pp. 169-172.
9. Trương Thi To Chinh, Luu Thi Kim Nhung, Do Thi Kim Hue, Phan Minh Giang, Phan Tong Son (2011), “Triterpenoids, flavonoids, diarylheptanoids, and the other compounds from Alnus nepalensis D. Don (Betulaceae)”, JournalofChemistry (Viet Nam), Vol. 49, (2ABC), pp. 196-202.
10. Minh Giang Phan, Thi To Chinh Truong, Tong Son Phan, Katsuyoshi Matsunami, Hideaki Otsuka (2011), “Three new dammarane glycosides from Betula alnoides”, Phytochemistry Letters, Vol. 4, pp. 179-182.
11. Minh Giang Phan, Thi To Chinh Truong, Tong Son Phan, Katsuyoshi Matsunami, Hideaki Otsuka (2011), “A new diarylheptanoid and a rare dammarane triterpenoid from Alnus nepalensis”, Chemistry of Natural Compound (accepted).
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