1. Full name: Doan Thi Huyen                                         2. Sex: Female

3. Date of birth: 16/06/1983                                            4. Place of birth: Thanh Hoa

5. Admission decision number: 4982/QD-SDH signed on 27/11/2013 by the Rector of VNU University of Science.

6. Changes in academic process: Non

7. Official thesis title: “Quantitative Analysis of selected active ingredients in antibiotics tablets by infrared spectra combined with multivariate linear regression”

8. Major: Analytical Chemistry                                                    9. Code: 62 44 01 18

10. Supervisors: Assoc. Prof., Dr. Ta Thi Thao,

      Dr. Bui Xuan Thanh.

11. Summary of the new findings of the thesis

- The suitable conditions of infrared spectroscopy for the determination of  quantify antibiotic active ingredients in the drug has been studied.

- PCR and PLS algorithm have been successfully used to determine an antibiotic active ingredient (cefixime, sulfaguanidine) and concurrently quantified a number of antibiotics in the same group including sulfaguanidine, sulfamethoxazole and Trimethoprime; Cephalexine, cefaclor and cefadroxil; Penicilline, ampiciline and amoxiciline; Cefotaxime and ceftriaxon; Cefixim and cefadroxil.

- The method has been validated and applied for the analysis of phamarceutical tablet and powdered samples.

12. Paratical applicability, if any:  This process allows for a non-destructive analysis of the sample, without the use of toxic and fast solvents, and results in appropriate screening of raw materials and rapid analysis of drug products.

13. Further research directions, if any: It is possible to use the established procedures to determine any substances in the drug using the appropriate multivariate regression model based on the infrared data. This is the initial results for developing of software on handheld devices. Open up new research directions on more complex objects such as functional foods, biological samples and foods.

14. Thesis-related publications:

[1] Thi-Thao Ta, Thi Huyen Doan, Xuan-Thanh Bui (2016), “Application of multivariate linear regressions for simultaneous determination of several coumpounds in a mixture”, proceedings of the scientific seminar of HNUE, pp.364-376

[2] Thi Huyen Doan, Thi-Thao Ta, Xuan-Thanh Bui, Thi Hue Vu (2016), “Study on the development of near infrared spectrocopy for rapid determination of sulfaguanidine in tablets”, Journal of analystical sciences, 21, pp.153-162.

[3] Thi-Thao Ta, Xuan-Thanh Bui, Thi Hue Vu, Thi Huyen Doan (2016). “Simultaneous quantitative analysis of sulfaguanidine, sulfamethoxazole and trimethoprim using principal component regression (PCR) based on near infrared spectra”, Journal of analystical sciences, 21, pp.127-134

[4] Thi Huyen Doan, Thu Thao Nguyen, Xuan-Thanh Bui, Thi-Thao Ta (2016). “Simutaneous determination of cefotaxime and ceftriaxone in powder for injection using near infrared (NIR) spectroscopy combined with partial least squared method (PLS)”, VNU journal of science, Vol. 32, pp.167-174.

[5] Thi Huyen Doan, Phuong Hoa Nguyen, Xuan-Thanh Bui, Thi-Thao Ta (2016), “Rapid and simultaneous determination of cefadroxil, cefalexin, cefaclor in tablets by near and midle infrared spectroscopy”, Journal of analystical sciences, 21, pp.94-101

 [6] Thi Huyen Doan, Ngoc Dinh Dang, Thi-Thao Ta, Xuan-Thanh Bui (2017), “Rapid and simultaneous determination of cefadroxil, cefixim in tablets by near and midle infrared spectroscopy”, Journal of analystical sciences, 22(1), pp.11-18.