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Official thesis title: Synthesis, structural studies and investigation of biological activity of complexes Pd(II), Ni(II) with some derivative thiosemicarbazones
1. Full name: Nguyen Thi Bich Huong
2. Sex: Female
3. Date of birth: 16/8/1982
4. Place of birth: Hai Duong
5. Admission decision number: 5429/SĐH Dated: October 30, 2008 of President of Vietnam National University.
6. Changes in academic process: No
7. Official thesis title: Synthesis, structural studies and investigation of biological activity of complexes Pd(II), Ni(II) with some derivative thiosemicarbazones
8. Major: Inorganic chemistry
9. Code: 62 44 25 01
10. Supervisors: Assoc. Prof. Dr. Trinh Ngoc Chau
11. Summary of the new findings of the thesis:
- 12 thiosemicarbazones with different substitutes at the N(4)- thiosemicarbazide: N(4)-methyl, N(4)-allyl and N(4)-phenyl of pyruvic acid, benzaldehyde and acetophenone were successfully synthesized and their chemical formula and structural formula were investigated by means of IR , 1H-NMR and 13C-NMR methods. The results show that the free ligands exist in thion tautomer
- 24 complexes of these thiosemicarbazones with palladium(II) and nickel(II) were synthesized and characterized by means of IR, NMR, MS methods. The obtained results allow giving conclusion about coordination style of thiosemicarbazones and structural formula of complexes.
- The software “Chem Bio Draw Ultra 11.0” has been using effectively to support the characterization and spectral assignment for 1H - NMR and 13C - NMR spectroscopy of the thiosemicarbazones.
- The software “isotope distribution calculator” also has been utilizing in the analysis of isotopic pattern of molecular-ion peaks for testing molecule formula of complexes. The fragmentary mechanism of Pd(thbz)2, Pd(pthbz)2, Ni(pthbz)2 and Ni(thacp)2 were also proposed with the utilization of software “Mass Fontier V.4.0 software”.
- Biological activity of 12 ligands, 24 complexes and 2 free ion Ni2+ and Pd2+ were tested on 06 types of bacteria and one type of fungus. The results show that complexation leads to increase biological activity of these thiosemicarbazones. Six complexes have good antibacterial activity. Among them, the Ni(mthacp)2 inhibit 5/7 of testing types bacteria and fungus.
- Six complexes, that have highest activity against to bacteria were also tested inhibitive activity against development of cancer cell and normal cell of. The results reveals that all tested compounds have higher inhibitive activity against cancer cell than the normal cell. So that, there is a gap of concentration of complexes in which the cancer cells were inhibited but not with normal cells.
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