1. Full name: Nguyen Thanh Trung                                 2. Sex: Male

3. Date of birth: 15/4/1977                                              4. Place of birth: Phu Tho

5. Admission decision number: 3972/QĐ-ĐHKHTN signed 24/11/2016

6. Changes in academic process:

Extended time by the decision number 567/QD-DHKHTN dated on 14/02/2020 and 318/QD-DHKHTN dated on 01/02/2021 by Rector of VNU University of Science.

7. Official thesis title: Research and assessment of pollution status of polycyclic aromatic hydrocarbons (PAHs) in urban dust and its toxic effects on AhR receptors

8. Major: Environmental Science                                                9. Code: 9440301.01

10. Supervisors: Dr. Le Huu Tuyen and Prof. Dr. Tran Thi Hong  

11. Summary of the new findings of the thesis

Researched and evaluated the pollution status of fine dust in some high traffic density in Hanoi to determine the need to conduct research on the assessment of total toxicity as well as the contribution of toxins in fine dust to the AhR receptor.

Researched and applied the PAH-CALUX gene expression testing method to evaluate the toxicity and stimulation of the AhR receptor of 16 PAHs, which have the risk of genetic mutations and cancer in fine dust (PM2.5, PM2.5-10, PM>10) in Hanoi.

BaP-equivalent toxicity and the contribution of compounds in 16 PAHs were evaluated to total toxicity, mutagenicity, and carcinogenic risk over life-time from exposure to fine dust in the population in research area.

12. Practical applicability, if any:

Provide data on the distribution of PAHs compounds in fine dust sizes (PM2.5, PM2.5-10, PM>10) in Hanoi.

Identify the main source of PAHs in the air in Hanoi, serving the management of urban air quality in Vietnam.

The toxicity of PAHs is the basis for evaluating the potential for carcinogenicity and mutagenicity in humans.

13. Further research directions, if any

Study of other PAHs that stimulate the AhR receptor to evaluate cytotoxic activity, aimed at elucidating the toxic contribution of these components to the total toxicity.

Research on the effects of PAHs on other receptors, such as the estrogen receptor.

Research on the effects as well as the contribution of PAHs compounds in fine dust emitted long-range from outside areas to inner city.

14. Thesis-related publications:

Nguyen Thanh Trung, Nguyen Minh Tue, Go Suzuki, Shin Takahashi, Shinsuke Tanabe, Pham Hung Viet, Do Phuc Quan, Phan Dinh Quang, Nguyen Thi Thu Nga, Tran Manh Tri, Pham Thi Thu Huong, Pham Thi Dau, Pham Chau Thuy, Dang Van Doan, Le Huu Tuyen (2017), "Toxicity identification and evaluation of AhR ligand activities in urban ambient particulate matter from Hanoi-Vietnam", 19th International Symposium on Pollutant Responses in Marine Organisms Japan, Japan.

Nguyen Thanh Trung, Le Thi Huyen, Nguyen Van Hao, Tran Thi Hong, Le Huu Tuyen (2020), "Assessment of fine dust poluttion (PM10, PM2,5) at HaNoi apartments", Environment Magazine issue 1, March, pp. 22-26.

Nguyen Thanh Trung, Dinh Thi Phuong Lan, Dam Hong Duan, Le Huu Tuyen (2020), "Design and build network monitoring dust PM2.5 and PM10 in real time", Journal of Science and Technology in Civil engineering 14(1V), pp. 114-120.

N. T. Trung, H. Q. Anh, N. M. Tue, G. Suzuki, S. Takahashi, S. Tanabe, N. M. Khai, T. T. Hong, P. T. Dau, P. C. Thuy, L. H. Tuyen (2021), "Polycyclic aromatic hydrocarbons in airborne particulate matter samples from Hanoi, Vietnam: Particle size distribution, aryl hydrocarbon ligand receptor activity, and implication for cancer risk assessment", Chemosphere 280, pp. 130720.

Nguyen Thanh Trung, Tran Thi Hong, Le Huu Tuyen, Pham Van Toi, Tran Thi Minh Nguyet (2021), "An initial assessment of the concentration of particulate matter, bacteria, and funggi in"several offices in Ha Noi, Environment Magazine  Special issue, pp. 70-75.