Aurora kinases play pivotal role in mitosis. Aurora kinase A controls centrosome duplication, spindle pole integrity as well as bipolar spindle formation. Aurora kinase B is part of the chromosome passenger complex (CPC) and through its co-factors, drives chromosome congression, bidirectional tension on kinetochores and spindle checkpoint signaling, as well as cytokinesis completion. Both CPC and Aurora kinases are exclusively expressed during mitosis and are up regulated in many tumors. Their overexpression correlates with the level of genomic instability within tumors and these proteins are therefore proposed as potential targets for cancer therapy. This review describes the interplay between Aurora kinases in mitosis and the different strategies that have been developed towards their targeting. © 2010.

Vu H.L., Hoang T.M.N., Favier B., Molla A.

205.pdf    Gửi cho bạn bè

Từ khóa : 1 cyclopropyl 3 [3 (5 morpholinomethyl 1h benzimidazol 2 yl) 1h pyrazol 4 yl]urea; 2 [[3 [4 [5 [2 (3 fluoroanilino) 2 oxoethyl] 1h pyrazol 3 ylamino] 7 quinazolinyloxy]propyl](ethyl)amino]ethyl dihydrogen phosphate; 4 [[9 chloro 7 (2,6 difluorophenyl) 5h pyrimido[5,4 d][2]benzazepin 2 yl]amino]benzoic acid; aki 001; amg 900; as 703569; aurora A kinase; aurora B kinase; aurora kinase inhibitor; c 1; chromosome protein; cyc 116; cyclopropanecarboxylic acid [4 [4 (4 methyl 1 piperazinyl) 6 (5 methyl 2h pyrazol 3 ylamino) 2 pyrimidinylthio]phenyl]amide; danusertib; enmd 2076; gsk 1070916; mk 6592; mln 8237; mp 529; om 137; pf 03814735; pha 60632; pha 680632; protein borealin; protein telophase disc 60; r 763; reversine; sns 314; survivin; tc 28; unclassified drug; unindexed drug; vx 667; acute granulocytic leukemia; acute lymphocytic leukemia; advanced cancer; aminotransferase blood level; cancer therapy; chronic myeloid leukemia; clinical trial; colon cancer; colorectal cancer; drug safety; drug targeting; drug withdrawal; febrile neutropenia; hematologic malignancy; human; IC 50; immunization; leukemia; lung non small cell cancer; lymphoma; melanoma; mitosis; multiple cycle treatment; multiple myeloma; myelodysplastic syndrome; myeloma; neuroblastoma; neutropenia; nonhodgkin lymphoma; nonhuman; ovary carcinoma; pancreas cancer; peritoneum cancer; prostate cancer; protein function; QT prolongation; review; RNA interference; side effect; solid tumor; somnolence; urogenital tract cancer; uterine cervix cancer; uterine tube carcinoma