By bioassay-guided isolation, phenylpropanoid-derived polyketides, including an unusual 5-methyl-3(2H)-furanone derivative (inotilone) with potent cyclooxygenase (COX) and xanthone oxidase (XO) inhibitory activities were obtained from the fruiting body of the mushroom Inonotus sp. © The Royal Society of Chemistry 2006.

Kemami Wangun H.V., Hartl A., Tam Kiet T., Hertweck C.

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Từ khóa : Derivatives; Enzyme inhibition; Metabolites; Polymers; Cyclooxygenase (COX); Inhibitory activities; Polyketides; Xanthone oxidase (XO); Bioassay; enzyme inhibitor; furan derivative; inotilone; macrolide; phenylpropionic acid derivative; prostaglandin synthase inhibitor; xanthine oxidase; article; Basidiomycetes; chemistry; drug antagonism; ion exchange chromatography; isolation and purification; methodology; spectroscopy; Basidiomycota; Chromatography, Ion Exchange; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Furans; Macrolides; Phenylpropionates; Spectrum Analysis; Xanthine Oxidase; Basidiomycota; Inonotus