A new ent-pimarane glucoside, named hythiemoside B (4), was isolated from the aerial part of Siegesbecikia orientate L. (Asteraceae) together with four known ent-pimarane-type diterpenoids: darutigenol (1), darutoside (2), hythiemoside A (3), and ent-(15R),16,19-trihydroxypimar-8(14)-ene 19-O-β-D-glucopyranoside (5). The structure of the new compound was elucidated by spectroscopic analyses and chemical transformation. The NMR data of compounds 1 (¹H-) and 5 (¹H- and ¹³C-) were also compiled in this study on the basis of 2D experiments. © 2005 Pharmaceutical Society of Japan.

Giang P.M., Son P.T., Otsuka H.

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Từ khóa : 15,16,19 trihydroxypimar 8(14) ene 19 o beta glucopyranoside; 16 acetoxypimar 8(14) ene 3beta diol; 3 o beta dextro glucoside; caffeic acid; darutigenol; darutoside; diterpenoid; geranylnerol derivative; germacranolide derivative; hythiemoside A; hythiemoside B; melampolide; pimarane; rutoside; sitosterol; stigmasterol; thiazolidine derivative; unclassified drug; abietane derivative; diterpene; arthritis; article; Asteraceae; carbon nuclear magnetic resonance; drug isolation; drug structure; furunculosis; hydrolysis; impetigo; menstruation disorder; nonhuman; proton nuclear magnetic resonance; rheumatic disease; siegesbeckia orientalis; stereochemistry; thin layer chromatography; traditional medicine; Viet Nam; chemistry; fast atom bombardment mass spectrometry; high performance liquid chromatography; infrared spectroscopy; isolation and purification; nuclear magnetic resonance spectroscopy; Asteraceae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Diterpenes; Diterpenes, Abietane; Hydrolysis; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Fast Atom Bombardment; Spectroscopy, Fourier Transform Infrared; Vietnam