Despite the ban on persistent organochlorines (OCs) in most of the developed nations, their usage continued until recently in many Asian developing countries including Vietnam, for agricultural purposes and vector-borne disease eradication programs. In this study, we collected human breast milk samples from the two big cities in Vietnam: Hanoi (n=42) and Hochiminh (n=44) and determined the concentrations of persistent OCs such as PCBs, DDT and its metabolites (DDTs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), chlordane compounds (CHLs) and tris-4-chlorophenyl- methane (TCPMe). The contamination pattern of OCs was in the order of DDTs > PCBs > HCHs > CHLs≈HCB≈TCPMe. Compilation of available data indicated that DDT residue levels in human breast milk from Vietnam were among the highest values reported for Asian developing countries as well as developed nations. This result suggests recent usage of DDTs in both north and south Vietnam. Interestingly, in both cities, the p,p'-DDT portion was higher in multiparas than those in primiparas. Considering the fact that the interval between the first and the second child of a mother in Vietnam is usually short, this result probably indicates continuous intake of DDTs in the population. Analysis of infant exposure to DDTs via breast milk suggested that the daily intake rates for number of individuals are close to or above the threshold for adverse effects which may raise concern on children health. © 2004 Elsevier Ltd. All rights reserved.

Minh N.H., Someya M., Minh T.B., Kunisue T., Iwata H., Watanabe M., Tanabe S., Viet P.H., Tuyen B.C.

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Từ khóa : Agriculture; Disease control; Metabolites; Risk assessment; Disease eradication; Organochlorides; Chlorine containing polymers; chlordane; chlorphenotane; hexachlorobenzene; hexachlorocyclohexane; methane; organochlorine derivative; polychlorinated biphenyl; DDT; health risk; milk; organochlorine; agriculture; article; Asia; bioaccumulation; breast milk; concentration (parameters); contamination; daily life activity; data analysis; eradication therapy; exposure; health; human; information processing; kinetics; maximum allowable concentration; metabolite; multipara; population research; risk assessment; Viet Nam; Age Factors; Chlordan; DDT; Developing Countries; Developmental Disabilities; Environmental Exposure; Female; Humans; Infant; Insecticides; Lindane; Milk, Human; Parity; Pesticide Residues; Polychlorinated Biphenyls; Risk Assessment; Vietnam; Asia; Eurasia; Southeast Asia; Viet Nam